Miche already posted about this, but I wanted to post also, for anyone who is on my flist and not hers.
Harley died at about 5:40 today. It became clear to us that it was time to let him go. In addition to the pretty rampant cancer (stage 5 lymphoma) he was facing additional challenges, including leukemia (due to cancer, not viral), loss of liver function, not enough protein in the blood and resulting leakage of fluid into his abdomen, and finally pneumonia. Treatment for all of these would have been grueling and the prognosis still grim. I truly believe we made the right decision to try and fight it, but the aggressive chemo took its toll.
We spent about a half hour with him before doing the deed. He was clearly happy to see us and after a while, ended up going to sleep while we were petting him, and the doctor was able to give injections without startling him, so he just dozed off and a few moments later, was gone.